منابع مشابه
Thymic Stromal Lymphopoietin (TSLP) promotes human eosinophil-basophil in situ hemopoieisis, and its secretion from human nasal epithelium is a function of TSLP genotype
Background Allergic diseases are characterized by tissue eosinophilic and basophilic inflammation. There is substantial evidence that this particular inflammatory profile results from the migration to tissues of a common eosinophil-basophil (Eo/B) progenitor that undergoes a differentiative process regulated by local cytokines, termed in situ hemopoiesis. We therefore investigated the role and ...
متن کاملTSLP-tickled mast cells
If you suffer a skin allergy, don’t be so quick to blame your T cells; they might not be behind it. Allakhverdi and colleagues now show on page 253 that mast cells, activated by a cytokine from epithelial cells, can jumpstart T cell–independent inflammation. Skin and epithelial cells irritated by allergens or by injury produce a cytokine called thymic stromal lymphopoietin (TSLP). This cytokine...
متن کاملBasophil production.
Factors influencing basophil production from the bone marrow of ovalbumin (OA)-sensitized guinea pigs have been examined in vitro. Autologous co-cultures of marrow and spleen cells from OA-immune animals contained significantly higher numbers of basophils after 7 d of liquid culture in the presence of OA, compared with control co-cultures or with marrow cultures alone (P < 0.005). Basophils inc...
متن کاملWhen is a mouse basophil not a basophil?
The identification and characterization of mouse basophils have historically been hampered by the extreme rarity of this cell type. Virtually no photomicrographs of hematologically stained (eg, Wright-Giemsa) examples of mouse basophils exist in the literature. However, 4 recent studies in the past 2 years have used flow cytometry and a defined set of cell-surface markers to identify and subseq...
متن کاملTSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling
Thymic stromal lymphopoietin (TSLP) is a four-helix bundle cytokine that plays a critical role in the regulation of immune responses and in the differentiation of hematopoietic cells. TSLP signals through a heterodimeric receptor complex consisting of an interleukin-7 receptor α chain and a unique TSLP receptor (TSLPR) [also known as cytokine receptor-like factor 2 (CRLF2)]. Cellular targets of...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2014
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.143.103